Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-activated platelets

被引：16

作者：

Laffargue, M ^{[1
]}

Monnereau, L ^{[1
]}

Tuech, J ^{[1
]}

Ragab, A ^{[1
]}

RagabThomas, J ^{[1
]}

Payrastre, B ^{[1
]}

Raynal, P ^{[1
]}

Chap, H ^{[1
]}

机构：

[1] HOP PURPAN,INSERM,U326,IFR30,F-31059 TOULON,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 238卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.7269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a specific polyclonal anti-Tec antibody, we have shown that Tec is expressed in human platelets. In addition, Tec was found to undergo tyrosine phosphorylation during platelet activation. The phosphorylation increased after 1 min and remained stable after 3 min of thrombin treatment. The tetrapeptide RGDS inhibited more than 90% of thrombin-induced tyrosine phosphorylation of Tec and blocked, its translocation to the cytoskeleton. These results suggest that Tec participates in platelet signaling downstream of integrin activation. (C) 1997 Academic Press.

引用

页码：247 / 251

页数：5

共 33 条

[1] CD28 IS ASSOCIATED WITH AND INDUCES THE IMMEDIATE TYROSINE PHOSPHORYLATION AND ACTIVATION OF THE TEC FAMILY KINASE ITK/EMT IN THE HUMAN JURKAT LEUKEMIC T-CELL LINE [J].