Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins

被引：78

作者：

Sirvent, P. ^{[1
,2
,3
,4
]}

Fabre, O. ^{[2
,3
,4
]}

Bordenave, S. ^{[2
,3
,4
]}

Hillaire-Buys, D. ^{[4
]}

De Mauverger, E. Raynaud ^{[2
,3
,4
]}

Lacampagne, A. ^{[2
,3
,4
]}

Mercier, J. ^{[2
,3
,4
]}

机构：

[1] Univ Blaise Pascal, Clermont Univ, EA 3533, Lab Adaptat Metab Exercice Condit Physiol & Patho, F-63171 Aubiere, France

[2] Univ Montpellier I, INSERM, U1046, F-34295 Montpellier, France

[3] Univ Montpellier 2, F-34295 Montpellier, France

[4] CHRU Montpellier, F-34295 Montpellier, France

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2012年 / 259卷 / 02期

关键词：

Skeletal muscle; Sta tins; Calcium homeostasis; Mitochondria; Muscle pain; SCANDINAVIAN SIMVASTATIN SURVIVAL; COA REDUCTASE INHIBITORS; CORONARY-HEART-DISEASE; SKELETAL-MUSCLE; MYOCARDIAL-INFARCTION; CHOLESTEROL LEVELS; DRUG-INTERACTIONS; IN-VIVO; MYOPATHY; RELEASE;

D O I：

10.1016/j.taap.2012.01.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The most common and problematic side effect of statins is myopathy. To date, the patho-physiological mechanisms of statin myotoxicity are still not clearly understood. In previous studies, we showed that acute application in vitro of simvastatin caused impairment of mitochondrial function and dysfunction of calcium homeostasis in human and rat healthy muscle samples. We thus evaluated in the present study, mitochondrial function and calcium signaling in muscles of patients treated with statins, who present or not muscle symptoms, by oxygraphy and recording of calcium sparks, respectively. Patients treated with statins showed impairment of mitochondrial respiration that involved mainly the complex I of the respiratory chain and altered frequency and amplitude of calcium sparks. The muscle problems observed in statin-treated patients appear thus to be related to impairment of mitochondrial function and muscle calcium homeostasis. confirming the results we previously reported in vitro. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：263 / 268

页数：6

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