Membrane microdomains and caveolae

被引:501
作者
Kurzchalia, TV [1 ]
Parton, RG
机构
[1] Max Planck Inst Mol Biol & Genet, Dresden, Germany
[2] Max Delbruck Ctr Mol Med, Dept Cell Biol, D-13092 Berlin, Germany
[3] Univ Queensland, Ctr Microscopy & Microanal, Dept Physiol & Pharmacol, Brisbane, Qld 4072, Australia
[4] Univ Queensland, Ctr Cellular & Mol Biol, Brisbane, Qld 4072, Australia
关键词
D O I
10.1016/S0955-0674(99)80061-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Glycosphingolipid- and cholesterol-enriched microdomains, or rafts, within the plasma membrane of eukaryotic cells have been implicated in many important cellular processes, such as polarized sorting of apical membrane proteins in epithelial cells and signal transduction. Until recently, however, the existence of such domains remained controversial. The past year has brought compelling evidence that microdomains indeed exist in living cells. In addition, several recent papers have suggested that caveolae, which are considered to be a specific form of raft, and caveolins, the major membrane proteins of caveolae, are involved in the dynamic cholesterol-dependent regulation of specific signal transduction pathways.
引用
收藏
页码:424 / 431
页数:8
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