Inheritable forms of medullary thyroid carcinoma

被引：13

作者：

Bachelot, A ^{[1
]}

Lombardo, F ^{[1
]}

Baudin, E ^{[1
]}

Bidart, JM ^{[1
]}

Schlumberger, M ^{[1
]}

机构：

[1] Inst Gustave Roussy, Dept Nucl Med & Endocrine Tumors, F-94805 Villejuif, France

来源：

BIOCHIMIE | 2002年 / 84卷 / 01期

关键词：

medullary thyroid carcinoma; RET gene; calcitonin;

D O I：

10.1016/S0300-9084(01)01364-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid that produce calcitonin. It accounts for 5-10% of all thyroid cancers. Hereditary MTC represents 20-30% of all MTCs. It can be transmitted with an autosomal dominant pattern, either as a single entity, familial MTC, or it can arise as part of a multiple endocrine neoplasia (MEN) syndrome type 2A or 2B. The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene. (C) 2002 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS.

引用

页码：61 / 66

页数：6

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