Purinergic signalling: ATP release

被引:416
作者
Bodin, P [1 ]
Burnstock, G [1 ]
机构
[1] UCL, Royal Free & Univ Coll Sch Med, Auton Neurosci Inst, London NW3 2PF, England
基金
英国惠康基金;
关键词
adenosine triphosphate; exocytosis; ATP binding cassette proteins; purinoceptors; neurotransmitter;
D O I
10.1023/A:1012388618693
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Adenosine triphosphate (ATP) has a fundamental intracellular role as the universal source of energy for all living cells. The demonstration of its release into the extracellular space and the identification and localisation of specific receptors on target cells have been essential in establishing, after considerable resistance, its extracellular physiological roles. It is now generally accepted that ATP is a genuine neurotransmitter both in the central and peripheral nervous Systems. As such, there are numerous arguments which prove that the release of ATP by nerve terminals is by exocytosis. In some non-neuronal cells, however, recent evidence suggests that ATP release could also be carrier-mediated and would involve ATP-binding cassette proteins (ABC), an ubiquitous family of transport ATPases.
引用
收藏
页码:959 / 969
页数:11
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