Reductive Cleavage of the Csp2-Csp3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups

被引：62

作者：

Chen, Kang ^{[1
,2
,3
]}

Li, Hu ^{[1
,2
,3
]}

Lei, Zhi-Quan ^{[5
]}

Li, Yang ^{[1
,2
,3
]}

Ye, Wen-He ^{[1
,2
,3
]}

Zhang, Li-Sheng ^{[1
,2
,3
]}

Sun, Jian ^{[5
]}

Shi, Zhang-Jie ^{[1
,2
,3
,4
]}

机构：

[1] Peking Univ, BNLMS, Beijing 100871, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Mol Engn, Beijing 100871, Peoples R China

[3] Peking Univ, Green Chem Ctr, Beijing 100871, Peoples R China

[4] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610068, Sichuan, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 39期

关键词：

C?C activation; cleavage reactions; hydrogenation; reaction mechanisms; rhodium; C-C-BOND; CARBON-CARBON BOND; ACTIVATION; HYDROGENATION; HYDROGENOLYSIS; REARRANGEMENT; INTERMEDIATE; DEALLYLATION; REMOVAL; OLEFINS;

D O I：

10.1002/anie.201204338

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cutting loose: 1,1-Biarylmethanol substrates undergo reductive cleavage of the C-C bond in the presence of a cationic Rh III catalyst and H 2 (see scheme; DG=directing group). Various functional groups are tolerated in the reaction system. Preliminary studies indicate that a five-membered rhodacycle intermediate, which then converts into a Rh III hydride species for the reduction, is involved in the catalytic cycle. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9851 / 9855

页数：5

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