EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

被引：335

作者：

Brabletz, Thomas ^{[1
,2
]}

机构：

[1] Univ Freiburg, Med Ctr, Dept Gen & Visceral Surg, Ctr Comprehens Canc, D-79106 Freiburg, Germany

[2] Univ Freiburg, Med Ctr, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany

来源：

CANCER CELL | 2012年 / 22卷 / 06期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR PROGRESSION;

D O I：

10.1016/j.ccr.2012.11.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activation of epithelial-mesenchymal transition (EMT) is important for cancer cell dissemination. Two papers in this issue of Cancer Cell (Ocana and colleagues and Tsai and colleagues) support the concept that the reversal of EMT is necessary for efficient metastatic colonization. Moreover, although EMT has been associated with sternness properties, one study indicates that they are not necessarily linked.

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收藏

页码：699 / 701

页数：3

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