Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor σL and roles in virulence and in global regulation of gene expression

被引：55

作者：

Dainese, E

Rodrigue, S

Delogu, G

Provvedi, R

Laflamme, L

Brzezinski, R

Fadda, G

Smith, I

Gaudreau, L

Palù, G

Manganelli, R

机构：

[1] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35100 Padua, Italy

[2] Univ Sherbrooke, Ctr Rech Mecanismes Fonctionnement Cellulaire, Sherbrooke, PQ J1K 2R1, Canada

[3] Univ Sacred Heart, Inst Microbiol, I-00168 Rome, Italy

[4] Univ Sherbrooke, Ctr Valorisat Divers Microbienne, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

[5] TB Ctr, Publ Hlth Res Inst, Newark, NJ USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 04期

关键词：

D O I：

10.1128/IAI.74.4.2457-2461.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RsLA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

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收藏

页码：2457 / 2461

页数：5

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