Rac1 GTPase: A "Rac" of All Trades

被引：277

作者：

Bosco, E. E. ^{[1
]}

Mulloy, J. C. ^{[1
]}

Zheng, Y. ^{[1
]}

机构：

[1] Cincinnati Childrens Hosp, Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Rac1; Rho GTPases; proliferation; cytoskeleton; survival; CELL-CELL ADHESION; RHO-FAMILY GTPASES; FACTOR-KAPPA-B; NUCLEAR-FACTOR; CDC42; GTPASES; BINDING PROTEINS; SPLICE VARIANT; KINASE PATHWAY; ACTIVATION; TRANSFORMATION;

D O I：

10.1007/s00018-008-8552-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.

引用

页码：370 / 374

页数：5

共 64 条

[1]

ABO A, 1992, J BIOL CHEM, V267, P16767

[2] Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation [J].

Akbar, H. ;

Kim, J. ;

Funk, K. ;

Cancelas, J. A. ;

Shang, X. ;

Chen, L. ;

Johnson, J. F. ;

Williams, D. A. ;

Zheng, Y. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (08) :1747-1755

[3] The role of Rho GTPases in disease development [J].

Boettner, B ;

Van Aelst, L .

GENE, 2002, 286 (02) :155-174

[4] REGULATION OF THE PHAGOCYTE RESPIRATORY BURST BY SMALL GTP-BINDING PROTEINS [J].

BOKOCH, GM .

TRENDS IN CELL BIOLOGY, 1995, 5 (03) :109-113

[5] Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway [J].

Brown, JL ;

Stowers, L ;

Baer, M ;

Trejo, J ;

Coughlin, S ;

Chant, J .

CURRENT BIOLOGY, 1996, 6 (05) :598-605

[6] Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization [J].

Cancelas, JA ;

Lee, AW ;

Prabhakar, R ;

Stringer, KF ;

Zheng, Y ;

Williams, DA .

NATURE MEDICINE, 2005, 11 (08) :886-891

[7] Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases [J].

Caron, E ;

Hall, A .

SCIENCE, 1998, 282 (5394) :1717-1721

[8] Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells [J].

Castilho, R. M. ;

Squarize, C. H. ;

Patel, V. ;

Millar, S. E. ;

Zheng, Y. ;

Molinolo, A. ;

Gutkind, J. S. .

ONCOGENE, 2007, 26 (35) :5078-5085

[9] Nox1-dependent reactive oxygen generation is regulated by Rac1 [J].

Cheng, Guangjie ;

Diebold, Becky A. ;

Hughes, Yasmin ;

Lambeth, J. David .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (26) :17718-17726

[10] Regulation of c-myc expression by PDGF through Rho GTPases [J].

Chiariello, M ;

Marinissen, MJ ;

Gutkind, JS .

NATURE CELL BIOLOGY, 2001, 3 (06) :580-586

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