Rolling Circle Amplification-Based DNA Origami Nanostructrures for Intracellular Delivery of Immunostimulatory Drugs

被引：142

作者：

Ouyang, Xiangyuan ^{[1
,2
]}

Li, Jiang ^{[1
,2
]}

Liu, Huajie ^{[1
,2
]}

Zhao, Bin ^{[1
,2
]}

Yan, Juan ^{[1
,2
,4
]}

Ma, Yinzhou ^{[3
]}

Xiao, Shoujun ^{[3
]}

Song, Shiping ^{[1
,2
]}

Huang, Qing ^{[1
,2
]}

Chao, Jie ^{[1
,2
]}

Fan, Chunhai ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Ctr, Div Phys Biol, Shanghai 201800, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Ctr, Bioimaging Ctr, Shanghai 201800, Peoples R China

[3] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

[4] Natl Engn Res Ctr Nanotechnol NERCN, Shanghai 200241, Peoples R China

来源：

SMALL | 2013年 / 9卷 / 18期

基金：

美国国家科学基金会;

关键词：

DNA nanostructures; rolling circle amplification; cellular uptake; drug delivery; DNA origami; BACTERIAL-DNA; FOLDING DNA; CPG MOTIFS; NANOTECHNOLOGY; NANOPARTICLES; PLATFORM; CARRIER; SHAPES;

D O I：

10.1002/smll.201300458

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several single-stranded scaffold DNA, obtained from rolling circle amplification (RCA), are folded by different staples to form DNA nanoribbons. These DNA nanoribbons are rigid, simple to design, and cost-effective drug carriers, which are readily internalized by mammalian cells and show enhanced immunostimulatory activity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3082 / 3087

页数：6

共 44 条

[1] Folding DNA into Twisted and Curved Nanoscale Shapes [J].