Generating, partitioning, targeting and functioning of superoxide in mitochondria

被引：178

作者：

Liu, SS

机构：

[1] State Key Lab. Biomembrane Memb. B., Institute of Zoology, Chinese Academy of Sciences, Haidian, Beijing 100080

来源：

BIOSCIENCE REPORTS | 1997年 / 17卷 / 03期

基金：

中国国家自然科学基金;

关键词：

superoxide; hydrogen peroxide; electron leak; proton leak; H+/2e; membrane potential; reactive oxygen cycle; heat production; mitochondria;

D O I：

10.1023/A:1027328510931

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, we proposed a hypothetical model of coexistence of ''Reactive oxygen cycle'' with Q cycle and H+ cycle in mitochondrial respiratory chain to combine both processes of univalent electron leak for production of superoxide and of proton leak across inner mitochondrial membrane. This review presents a more detailed description of this model and summarizes the supporting experimental evidence obtained.

引用

页码：259 / 272

页数：14

共 43 条

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