In vivo angiotensin II receptor blockade and converting enzyme inhibition on canine aortic viscoelasticity

被引:27
作者
Barra, JG
Levenson, J
Armentano, RL
Fischer, EIC
Pichel, RH
Simon, A
机构
[1] Hop Broussais, INSERM, Ctr Med Prevent Cardiovasc, F-75674 Paris 14, FRANCE
[2] Rene Favaloro Univ Fdn, Basic Sci Res Inst, RA-1078 Buenos Aires, DF, ARGENTINA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1997年 / 272卷 / 02期
关键词
renin-angiotensin system; renovascular hypertension; viscosity index; losartan; compliance-pressure curves;
D O I
10.1152/ajpheart.1997.272.2.H859
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The influence of the renin-angiotensin system (RAS) on the aortic wall mechanical properties under angiotensin I converting enzyme inhibition (enalaprilat, 0.3 mg/kg iv) or angiotensin II receptor (AT(1)) blockade (E-3174, 1 mg/kg iv) was examined in eight normotensive and eight renovascular hypertensive conscious dogs. Aortic diameter (D; sonomicrometry)-pressure (P; microtransducer) hysteresis loops during steady state and during rapid distal aortic occlusion allowed (after hysteresis elimination) calculation of the aortic wall viscosity index, the purely elastic P-D relationship, and derivation into compliance-pressure curves. At the early stage of renovascular hypertension when activation of RAS is more pronounced, aortic wall stiffness and wall viscosity were increased as compared with normotensive states. Blood pressure remained unchanged in normotensive animals and was reduced during hypertension after antihypertensive treatments. In hypertensive animals, enalaprilat and E-3174 decreased viscosity index and shifted the compliance-pressure curve upward with respect to pretreatment conditions. In normotensive dogs, whereas E-3174 did not change the compliance-pressure curve and viscosity index, enalaprilat increased compliance and reduced viscosity index. We concluded that in normotensive dogs converting enzyme inhibition modifies arterial viscoelastic parameters by angiotensin-independent mechanisms that contribute to the modulation of the buffering function of large arteries.
引用
收藏
页码:H859 / H868
页数:10
相关论文
共 33 条
[1]   EFFECTS OF HYPERTENSION ON VISCOELASTICITY OF CAROTID AND FEMORAL ARTERIES IN HUMANS [J].
ARMENTANO, R ;
MEGNIEN, JL ;
SIMON, A ;
BELLENFANT, F ;
BARRA, J ;
LEVENSON, J .
HYPERTENSION, 1995, 26 (01) :48-54
[2]   MECHANICAL PRESSURE VERSUS INTRINSIC EFFECTS OF HYPERTENSION ON LARGE ARTERIES IN HUMANS [J].
ARMENTANO, R ;
SIMON, A ;
LEVENSON, J ;
CHAU, NP ;
MEGNIEN, JL ;
PICHEL, R .
HYPERTENSION, 1991, 18 (05) :657-664
[3]   ASSESSMENT OF ELASTIN AND COLLAGEN CONTRIBUTION TO AORTIC ELASTICITY IN CONSCIOUS DOGS [J].
ARMENTANO, RL ;
LEVENSON, J ;
BARRA, JG ;
FISCHER, EIC ;
BREITBART, GJ ;
PICHEL, RH ;
SIMON, A .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (06) :H1870-H1877
[4]   ARTERIAL-WALL MECHANICS IN CONSCIOUS DOGS - ASSESSMENT OF VISCOUS, INERTIAL, AND ELASTIC-MODULI TO CHARACTERIZE AORTIC-WALL BEHAVIOR [J].
ARMENTANO, RL ;
BARRA, JG ;
LEVENSON, J ;
SIMON, A ;
PICHEL, RH .
CIRCULATION RESEARCH, 1995, 76 (03) :468-478
[5]   ASSESSMENT OF SMOOTH-MUSCLE CONTRIBUTION TO DESCENDING THORACIC AORTIC ELASTIC MECHANICS IN CONSCIOUS DOGS [J].
BARRA, JG ;
ARMENTANO, RL ;
LEVENSON, J ;
FISCHER, EIC ;
PICHEL, RH ;
SIMON, A .
CIRCULATION RESEARCH, 1993, 73 (06) :1040-1050
[6]   VASODEPRESSOR ROLE OF ENDOGENOUS BRADYKININ ASSESSED BY A BRADYKININ ANTAGONIST [J].
BENETOS, A ;
GAVRAS, H ;
STEWART, JM ;
VAVREK, RJ ;
HATINOGLOU, S ;
GAVRAS, I .
HYPERTENSION, 1986, 8 (11) :971-974
[7]   SYMPATHETIC ACTIVATION DECREASES MEDIUM-SIZED ARTERIAL COMPLIANCE IN HUMANS [J].
BOUTOUYRIE, P ;
LACOLLEY, P ;
GIRERD, X ;
BECK, L ;
SAFAR, M ;
LAURENT, S .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1994, 267 (04) :H1368-H1376
[8]  
CABRERAFISCHER E, 1991, CIRC RES, V68, P1549
[9]   LOCAL HORMONAL FACTORS (INTRACRINE, AUTOCRINE, AND PARACRINE) IN HYPERTENSION [J].
CARRETERO, OA ;
SCICLI, AG .
HYPERTENSION, 1991, 18 (03) :58-69
[10]  
COHEN ML, 1982, J PHARMACOL EXP THER, V220, P63