Rapid determination of pharmacokinetic properties of new chemical entities:: In vivo approaches

被引：31

作者：

Cox, KA ^{[1
]}

White, RE ^{[1
]}

Korfmacher, WA ^{[1
]}

机构：

[1] Schering Plough Corp, Inst Res, Dept Drug Metab & Pharmacokinet, Kenilworth, NJ 07033 USA

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2002年 / 5卷 / 01期

关键词：

D O I：

10.2174/1386207023330534

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

There is a continuing need for increased throughput in the evaluation of new chemical entities in terms of their pharmacokinetic (PK) parameters as part of new drug discovery. This review summarizes various approaches that have been used to increase throughput in this area. The article divides the approaches into two areas: assay enhancement and sample reduction.

引用

页码：29 / 37

页数：9

共 60 条

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