Isoprenoid-like alkylations in polyketide biosynthesis

被引：88

作者：

Calderone, Christopher T. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NATURAL PRODUCT REPORTS | 2008年 / 25卷 / 05期

关键词：

D O I：

10.1039/b807243d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyketides are secondary metabolites biosynthesized by the iterative Claisen condensation of malonate units. Despite utilizing only a small set of biochemical transformations, the polyketide biosynthetic machinery yields products Of Striking structural complexity and diversity. Recently, a new polyketicle alkylation pathway was characterized that allows access to "beta-branched" structures. This Highlight will describe this alkylation sequence, with special emphasis on its parallels to isoprenoid biosynthesis from primary metabolism and the scope of structures accessible via this pathway.

引用

页码：845 / 853

页数：9

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