Ability of a new oral nicotine substitute to reduce smoking urge in moderate smokers

被引：7

作者：

Demazières, A

Luthringer, R

Coppel, E

Gilles, C

Fleury, C

Roegel, JC

Delarue, A

Laur, C

Lagrue, G

机构：

[1] FORENAP, Res Inst Neurosci Pharmacol & Psychiat, F-68250 Rouffach, France

[2] Inst Rech Pierre Fabre, Dept Innovat Dev, F-31527 Ramonville St Agne, France

[3] Hop Albert Chenevier, Serv Tabacol, F-94000 Creteil, France

来源：

ADDICTIVE BEHAVIORS | 2006年 / 31卷 / 03期

关键词：

nicotine replacement therapy; smoking urge; withdrawal symptom; lozenge;

D O I：

10.1016/j.addbeh.2005.05.017

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The aim of this study was to assess the effectiveness of a new nicotine lozenge (Nicopass (R) 1.5mg) in reducing smoking urge after an overnight abstinence. Twenty-four moderate smokers participated in a randomized, double-blind, placebo-controlled, 2-period crossover trial. The results showed that 1.5 mg-nicotine lozenge is superior to placebo in reducing smoking urge (p = 0.0001). In addition, nicotine lozenge, but not placebo, significantly improved vigilance and psychomotor performances (p < 0.05) and displayed a cardiac chronotropic effect. Thus, the 1.5-mg nicotine lozenge appears as an effective aid to alleviate acute tobacco withdrawal symptoms in moderate smokers. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：537 / 543

页数：7

共 12 条

[1] USE OF ANALOG SCALES IN RATING SUBJECTIVE FEELINGS [J].