Evolutionary origin of SL-addition trans-splicing:: still an enigma

被引：63

作者：

Nilsen, TW ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Ctr RNA Mol Biol, Cleveland, OH 44106 USA

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 12期

关键词：

D O I：

10.1016/S0168-9525(01)02499-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Spliced-leader (SL) trans-splicing is an essential step in pre-mRNA maturation in a variety of lower eukaryotic organisms. However, this processing pathway is absent in mammals, insects, yeast and plants. The patchy phylogenetic distribution of SL trans-splicing is consistent with either 'multiple gain' or 'multiple loss' evolutionary scenarios. Recent studies show that two additional metazoan phyla carry out SL trans-splicing, significantly increasing its phylogenetic range. However, it remains unclear whether this unusual type of splicing is an ancestral or an acquired trait.

引用

页码：678 / 680

页数：3

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