Binding biomolecules with designed, hydrogen-bonding receptors

被引：29

作者：

Bell, TW ^{[1
]}

Hext, NM ^{[1
]}

Khasanov, AB ^{[1
]}

机构：

[1] Univ Nevada, Dept Chem 216, Reno, NV 89557 USA

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 12期

关键词：

D O I：

10.1351/pac199870122371

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An approach to the design of artificial receptors is described involving the fusion of several six-membered rings, preorganizing nitrogen and oxygen hydrogen bonding sites. A hexagonal lattice chemosensor extracts the blood metabolite creatinine into water and acts as a chromogenic reagent for this clinical analyte. Another receptor binds urea via six hydrogen bonds, forming a complex that is stable even in DMSO. A water-soluble receptor has now been synthesized that recognizes the guanidinium sidechain of arginine in aqueous media.

引用

页码：2371 / 2377

页数：7

共 17 条

[1] Bell T., 1990, INCLUSION PHENOMENA, P49
[2] SYNTHESIS OF NEW TORANDS AND NEW USES FOR OLD TORANDS
BELL, TW
CRAGG, PJ
DREW, MGB
FIRESTONE, A
KWOK, ADI
LIU, J
LUDWIG, RT
PAPOULIS, AT
[J]. PURE AND APPLIED CHEMISTRY, 1993, 65 (03) : 361 - 366
[3] HEXAGONAL LATTICE HOSTS FOR UREA - A NEW SERIES OF DESIGNED HETEROCYCLIC RECEPTORS
BELL, TW
LIU, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (11) : 3673 - 3674
[4] Molecular architecture. 2. Synthesis and metal complexation of heptacyclic terpyridyl molecular clefts
Bell, TW
Cragg, PJ
Firestone, A
Kwok, ADI
Liu, J
Ludwig, R
Sodoma, A
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (07) : 2232 - 2243
[5] DETECTION OF CREATININE BY A DESIGNED RECEPTOR
BELL, TW
HOU, Z
LUO, Y
DREW, MGB
CHAPOTEAU, E
CZECH, BP
KUMAR, A
[J]. SCIENCE, 1995, 269 (5224) : 671 - 674
[6] A hydrogen-bonding receptor that binds urea with high affinity
Bell, TW
Hou, Z
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (13-14): : 1536 - 1538
[7] TORANDS - RIGID TOROIDAL MACROCYCLES - CALCIUM SEQUESTRATION BY A MEMBER OF THIS NEW LIGAND CLASS
BELL, TW
FIRESTONE, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (25) : 8109 - 8111
[8] Bell TW, 1997, NATO ADV SCI I C-MAT, V492, P121
[9] Bell TW, 1995, NATO ADV SCI INST SE, V473, P161
[10] TORAND SYNTHESIS BY TRIMERIZATION - NEW RECEPTORS FOR GUANIDINIUM
BELL, TW
LIU, J
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1990, 29 (08) : 923 - 925

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