Human type 1 innate lymphoid cells accumulate in inflamed mucosa! tissues

被引：810

作者：

Bernink, Jochem H. ^{[1
]}

Peters, Charlotte P. ^{[1
,2
]}

Munneke, Marius ^{[3
,4
]}

te Velde, Anje A. ^{[1
]}

Meijer, Sybren L. ^{[5
]}

Weijer, Kees ^{[4
]}

Hreggvidsdottir, Hulda S. ^{[1
,6
]}

Heinsbroek, Sigrid E. ^{[1
]}

Legrand, Nicolas ^{[4
]}

Buskens, Christianne J. ^{[7
]}

Bemelman, Willem A. ^{[7
]}

Mjosberg, Jenny M. ^{[1
,8
]}

Spits, Hergen ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

[5] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

[6] Univ Amsterdam, Acad Med Ctr, Dept Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands

[7] Univ Amsterdam, Acad Med Ctr, Dept Surg, NL-1105 AZ Amsterdam, Netherlands

[8] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Dept Med,Ctr Infect Med, Stockholm, Sweden

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 03期

关键词：

TRANSCRIPTION FACTOR GATA3; NATURAL-KILLER; T-BET; INDUCER CELLS; EXPRESSION; CYTOKINES; GAMMA; DISTINCT; MICE;

D O I：

10.1038/ni.2534

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) are effectors of innate immunity and regulators of tissue modeling. Recently identified ILC populations have a cytokine expression pattern that resembles that of the helper T cell subsets T(H)2, T(H)17 and T(H)22. Here we describe a distinct ILC subset similar to T(H)1 cells, which we call 'ILC1'. ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-gamma (IFN-gamma). ILC1 cells were distinct from natural killer (NK) cells as they lacked perforin, granzyme B and the NK cell markers CD56, CD16 and CD94, and could develop from ROR gamma t(+) ILC3 under the influence of IL-12. The frequency of the ILC1 subset was much higher in inflamed intestine of people with Crohn's disease, which indicated a role for these IFN-gamma-producing ILC1 cells in the pathogenesis of gut mucosal inflammation.

引用

页码：221 / 229

页数：9

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