Diurnal salivary cortisol in pediatric posttraumatic stress disorder

被引:194
作者
Carrion, VG [1 ]
Weems, CF [1 ]
Ray, RD [1 ]
Glaser, B [1 ]
Hessl, D [1 ]
Reiss, AL [1 ]
机构
[1] Stanford Univ, Div Child & Adolescent Psychiat & Child Dev, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
关键词
cortisol; PTSD; HPA axis; chronic stress; development;
D O I
10.1016/S0006-3223(01)01310-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of post-traumatic stress disorder (PTSD). Additional information on basal cortisol levels in children exposed to trauma and experiencing PTSD symptoms mail contribute to the understanding of the role of this axis in PTSD. Methods: Fifty-one children (30 boys and 21 girls, mean age 10.7 years) with a history of exposure to trauma and PTSD symptoms were compared with 31 age- and gender-matched healthy control subjects. Salivary cortisol was obtained from participants during home measurements and was collected four times a day (prebreakfast, prelunch, predinner, and prebed) for up to 3 consecutive days. Results: The clinical group demonstrated significantly, elevated cortisol levels when compared with the control group. In addition, exploratory analyses revealed that girls with PTSD symptoms had significantly, elevated cortisol levels when compared with boys with PTSD symptoms. Conclusions: The physiologic response of children with history of trauma and with PTSD symptoms may, be characterized by heightened adrenal activity. (C) 2002 Society of Biological Psychiatry.
引用
收藏
页码:575 / 582
页数:8
相关论文
共 37 条
[1]  
Achenbach T.M., 1991, MANUAL CHILD BEHAV C
[2]   THE DEVELOPMENT OF A CLINICIAN-ADMINISTERED PTSD SCALE [J].
BLAKE, DD ;
WEATHERS, FW ;
NAGY, LM ;
KALOUPEK, DG ;
GUSMAN, FD ;
CHARNEY, DS ;
KEANE, TM .
JOURNAL OF TRAUMATIC STRESS, 1995, 8 (01) :75-90
[3]   Posttraumatic stress disorder, exposure to combat, and lower plasma cortisol among Vietnam veterans: Findings and clinical implications [J].
Boscarino, JA .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1996, 64 (01) :191-201
[4]  
Breslau N, 1997, ARCH GEN PSYCHIAT, V54, P1044
[5]  
CARRION V, IN PRESS J AM ACAD C
[6]   Prevalence of PTSD in a community sample of older adolescents [J].
Cuffe, SP ;
Addy, CL ;
Garrison, CZ ;
Waller, JL ;
Jackson, KL ;
McKeown, RE ;
Chilappagari, S .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1998, 37 (02) :147-154
[7]   Developmental traumatology Part I: Biological stress systems [J].
De Bellis, MD ;
Baum, AS ;
Birmaher, B ;
Keshavan, MS ;
Eccard, CH ;
Boring, AM ;
Jenkins, FJ ;
Ryan, ND .
BIOLOGICAL PSYCHIATRY, 1999, 45 (10) :1259-1270
[8]   HYPOTHALAMIC-PITUITARY-ADRENAL AXIS DYSREGULATION IN SEXUALLY ABUSED GIRLS [J].
DEBELLIS, MD ;
CHROUSOS, GP ;
DORN, LD ;
BURKE, L ;
HELMERS, K ;
KLING, MA ;
TRICKETT, PK ;
PUTNAM, FW .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (02) :249-255
[9]  
DUKE PM, 1980, PEDIATRICS, V66, P918
[10]  
Goenjian AK, 1996, AM J PSYCHIAT, V153, P929