Dynamic multiphosphorylation passwords for activity-dependent gene expression

被引：94

作者：

Deisseroth, K ^{[1
]}

Tsien, RW

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA

来源：

NEURON | 2002年 / 34卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(02)00664-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mechanism (phosphorylating Ser133) while generating distinct patterns of gene expression? We review three Neuron articles that highlight novel ways Ca2+ signals can trigger multiple phosphorylation events working in combination to control CREB and its interaction with coactivator molecules.

引用

页码：179 / 182

页数：4

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