Potential role of curcumin and taurine combination therapy on human myeloid leukemic cells propagated in vitro

被引：12

作者：

El-Houseini, Motawa E. ^{[1
]}

Refaei, Mohammed Osman ^{[2
]}

Amin, Ahmed Ibrahim ^{[2
]}

Abol-Ftouh, Mahmoud A. ^{[1
]}

机构：

[1] Cairo Univ, Dept Canc Biol, NCI, Cairo, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

LEUKEMIA & LYMPHOMA | 2013年 / 54卷 / 10期

关键词：

Acute myeloid leukemia (AML); chronic myeloid leukemia (CML); curcumin-taurine; immunophenotypic profile; interferon-gamma; INTERFERON-GAMMA; APOPTOSIS; DEATH; INHIBITION; EXPRESSION; CHLORAMINE; GROWTH; CYCLE;

D O I：

10.3109/10428194.2013.776167

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Curcumin and taurine are natural products that have been used in this study evaluating their therapeutic effect on myeloid leukemic cells propagated in vitro. Sixty patients with myeloid leukemia and 30 healthy volunteers were enrolled in the study. All patient groups were admitted to the Medical Oncology Department of the National Cancer Institute, Cairo University. There were statistically significant differences between treated leukemic cells compared to normal mononuclear leukocytes in cell density, interferon-g and immunophenotypic profile, mainly CD4+, CD8+ and CD25+. This work highlights the possibility of using curcumin and taurine as a potential useful therapy in the management of patients suffering from chronic and acute myeloid leukemias.

引用

页码：2281 / 2287

页数：7

共 40 条

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