Polyphenolic compounds of Sideritis lycia and their anti-inflammatory activity

Four phenylpropanoid glycosides lavandulifolioside 1, martynoside 2, verbascoside (=acteoside) 3 cmd leucosceptoside A 4, were isolated from aerial parts of Sideritis lycia Boiss. et Heldr. (Lamiaceae). Their structures were determined by chromatographic and spectroscopic methods (UV, IR, H-1-NMR, C-13-NMR, FAB-MS). These compounds and flavonoid glycosides isolated from the same plant in our previously study were screened for their anti-inflammatory activity using the carrageenan-induced mouse paw edema test. The active compounds were then investigated for their effect on gastric ulceration. Although flavonoid glycosides showed higher activity than the phenyl-propanoid glycosides, the gastric ulceration effect of phenylpropanoid glycosides was less than flavonoid glycosides.