Parasite Polymorphism May Serve to Enhance Fitness in Different Host Environments

被引：4

作者：

Takano-Lee, Miwako ^{[1
]}

Edman, John D. ^{[1
,3
]}

Herrera, Enrique M. ^{[2
]}

Tussie-Luna, Maria I. ^{[2
]}

Pereira, Miercio E. A. ^{[2
]}

机构：

[1] Univ Massachusetts, Dept Entomol, Amherst, MA 01003 USA

[2] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA

[3] Univ Calif Davis, Vet Med Ctr Vector Borne Dis Res, Davis, CA 95616 USA

来源：

VECTOR-BORNE AND ZOONOTIC DISEASES | 2002年 / 2卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Rhodnius prolixus; Trypanosoma cruzi; Parasite polymorphism; Chagas' disease;

D O I：

10.1089/153036602760260751

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Phenotypic expression of trans-sialidase (TS) by Trypanosoma cruzi (Silvio strain) is restricted to a subpopulation (20-30%) of broad trypomastigotes (TS+ parasites), while the larger subpopulation of slender trypomastigotes lacks TS expression (TS- parasites). Rhodnius prolixus nymphs were infected with fractionated T. cruzi parasite populations (Silvio strain). Bugs ingesting TS- parasites produced significantly higher parasite loads than bugs ingesting either TS+ parasites or unfractionated populations. The addition of 1.0 mu g of TS monoclonal antibody (TCN-2)/ml of blood meal to TS+ populations increased parasite populations to levels comparable to those of TS- populations. In contrast, the addition of exogenous TS to TS- parasite blood meals significantly reduced parasite loads to levels comparable to bugs ingesting TS+ parasites. These results suggest that T. cruzi trypomastigote polymorphism may serve to enhance survival in different host environments.

引用

页码：29 / +

页数：9

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