Total synthesis of 4(RS)-F4t-isoprostane methyl ester

被引：22

作者：

Durand, T

Guy, A

Vidal, JP

Viala, J

Rossi, JC

机构：

[1] Univ Montpellier 1, Fac Pharm, CNRS, UMR 5074, F-34060 Montpellier, France

[2] Fac Sci & Tech St Jerome, CNRS, UMR 6516, F-13397 Marseille 20, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)00508-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of 4(RS)-F-4t-isoprostane methyl ester I is described using diacetone-D-glucose as starting material. This new isoprostane (neuroprostane) would be very useful in neurological studies as a potent lipid peroxidation index to obtain an integrated assessment of oxidative stress in the human brain. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：3859 / 3862

页数：4

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