New avenues for the prevention of colorectal cancer: targeting cyclo-oxygenase-2 activity

被引：8

作者：

Gupta, RA

DuBois, RN ^{[1
]}

Wallace, MC

机构：

[1] Vanderbilt Univ, Med Ctr, Div Gastroenterol, Nashville, TN 37232 USA

[2] Dept Vet Affairs Med Ctr, Nashville, TN 37212 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2002年 / 16卷 / 06期

关键词：

cyclo-oxygenase; colon cancer; prevention; angiogenesis;

D O I：

10.1053/bega.2002.0353

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Carcinoma of the colon and/or rectum represents the second most common gastrointestinal malignancy worldwide. Despite this prevalence, current therapeutic regimens remain largely ineffectual, particularly when the disease is diagnosed at an advanced stage. Recent work in the field of colorectal cancer has established that a chronic intake of non steroidal anti-inflammatory drugs can reduce the risk of developing colorectal cancer. Although the precise mechanism(s) by which these drugs inhibit tumour growth is not completely understood, it is likely that at least a part of their anti-tumorigenic effects results from an inhibition of the cyclo-oxygenase-2 enzyme. This chapter will focus on this emerging research area and the promise it brings for identifying new strategies for the prevention of colorectal cancer.

引用

收藏

页码：945 / 956

页数：12

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