Quantitative evaluation of the rate of myocardial interstitial fibrosis using a personal computer

被引:16
作者
Kitamura, M
Shimizu, M
Kita, Y
Yoshio, H
Ino, H
Misawa, K
Matsuyama, T
Mabuchi, H
机构
[1] Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa
来源
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION | 1997年 / 61卷 / 09期
关键词
computer analysis; myocardial interstitial fibrosis; point-counting method; hydroxyproline;
D O I
10.1253/jcj.61.781
中图分类号
N09 [自然科学史]; B [哲学、宗教];
学科分类号
01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;
摘要
We investigated the reliability and reproducibility of an image-analyzing system run on a personal computer for measurement of myocardial interstitial fibrosis. Measurements of myocardial interstitial fibrosis in right ventricular endomyocardial biopsies obtained from patients with hypertrophic cardiomyopathy determined by this image-analyzing system were compared with measurements determined by the point-counting method. We also investigated the correlation between measurements of interstitial fibrosis obtained by image analysis and biochemical measurements of myocardial levels of hydroxyproline in normal and cardiomyopathic hamsters. The intra-and interobserver variability were significantly lower for measurements obtained by the image-analyzing system than for measurements obtained by the point-counting system. Reproducibility was superior with the image-analyzing method. The rate of myocardial interstitial fibrosis determined by the computer image-analyzing method was positively correlated with the hydroxyproline measurement (r=0.89). Our results suggest that an image-analyzing system using a personal computer provides reproducible results with a high level of reliability.
引用
收藏
页码:781 / 786
页数:6
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