Lack of influence of the anaerobic [NiFe] hydrogenase and L-1,2 propanediol oxidoreductase on the outcome of Actinobacillus pleuropneumoniae serotype 7 infection

被引：9

作者：

Baltes, N

Kyaw, S

Hennig-Pauka, I

Gerlach, GF

机构：

[1] Hannover Sch Vet Med, Inst Microbiol, Dept Infect Dis, D-30173 Hannover, Germany

[2] Hannover Sch Vet Med, Clin Pigs & Small Ruminants, D-30173 Hannover, Germany

来源：

VETERINARY MICROBIOLOGY | 2004年 / 102卷 / 1-2期

关键词：

Actinobacillus pleuropneumoniae; anaerobic metabolism; NiFe] hydrogenase; L-1,2 propanediol oxidoreductase; deletion mutants;

D O I：

10.1016/j.vetmic.2004.05.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The genes for the large subunit of [NiFe] hydrogenase 2, (hybB) and for L-1,2 propanediol oxidoreductase (fucO), were identified in an Actinobacillus (A.) pleuropneumoniae serotype 7 strain. Based on the hypothesis that adaptation to anaerobic conditions in damaged lung tissue may play a role in A. pleuropneumoniae persistence in host tissues, deletion mutants with a deletion in the hybB or the fucO gene were constructed and examined in an aerosol infection model. Deletion of the hybB or fucO genes appeared to have no significant effect on A. pleuropneumoniae virulence. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：67 / 72

页数：6

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