Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

被引：292

作者：

Chen, Fengju ^{[1
]}

Zhang, Yiqun ^{[1
]}

Senbabaoglu, Yasin ^{[2
]}

Ciriello, Giovanni ^{[3
]}

Yang, Lixing ^{[4
]}

Reznik, Ed ^{[2
]}

Shuch, Brian ^{[5
]}

Micevic, Goran ^{[6
,7
]}

De Velasco, Guillermo ^{[8
]}

Shinbrot, Eve ^{[9
]}

Noble, Michael S. ^{[10
,11
]}

Lu, Yiling ^{[12
]}

Covington, Kyle R. ^{[9
]}

Xi, Liu ^{[9
]}

Drummond, Jennifer A. ^{[9
]}

Muzny, Donna ^{[9
]}

Kang, Hyojin ^{[13
]}

Lee, Junehawk ^{[13
,14
]}

Tamboli, Pheroze ^{[15
]}

Reuter, Victor ^{[16
]}

Shelley, Carl Simon ^{[17
]}

Kaipparettu, Benny A. ^{[1
,18
]}

Bottaro, Donald P. ^{[19
]}

Godwin, Andrew K. ^{[20
]}

Gibbs, Richard A. ^{[9
,18
]}

Getz, Gad ^{[10
,11
,21
]}

Kucherlapati, Raju ^{[22
,23
,24
]}

Park, Peter J. ^{[4
]}

Sander, Chris ^{[2
]}

Henske, Elizabeth P. ^{[10
,11
,23
,24
]}

Zhou, Jane H. ^{[25
]}

Kwiatkowski, David J. ^{[10
,11
,23
,24
]}

Ho, Thai H. ^{[26
]}

Choueiri, Toni K. ^{[8
]}

Hsieh, James J. ^{[27
]}

Akbani, Rehan ^{[28
]}

Mills, Gordon B. ^{[12
]}

Hakimi, A. Ari ^{[29
]}

Wheeler, David A. ^{[9
,18
]}

Creighton, Chad J. ^{[1
,9
,28
,30
]}

机构：

[1] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA

[2] Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10065 USA

[3] Univ Lausanne, Dept Computat Biol, CH-1015 Lausanne, Switzerland

[4] Harvard Univ, Sch Med, Dept Biomed Informat, Boston, MA 02115 USA

[5] Yale Univ, Sch Med, Dept Urol, New Haven, CT 06520 USA

[6] Yale Univ, Dept Dermatol, New Haven, CT 06510 USA

[7] Yale Univ, Dept Pathol, New Haven, CT 06510 USA

[8] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[9] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[10] MIT, Eli & Edythe L Broad Inst, Cambridge, MA 02142 USA

[11] Harvard Univ, Cambridge, MA 02142 USA

[12] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77054 USA

[13] Korea Inst Sci & Technol Informat KAIST, Dept Convergence Technol Res, Daejeon 305806, South Korea

[14] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 305806, South Korea

[15] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[16] Mem Sloan Kettering Canc, Dept Pathol, New York, NY 10065 USA

[17] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53726 USA

[18] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[19] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA

[20] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA

[21] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[22] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[23] Brigham & Womens Hosp, Boston, MA 02115 USA

[24] Harvard Univ, Sch Med, Boston, MA 02115 USA

[25] Tufts Univ, Sch Med, Tufts Med Ctr, Dept Pathol & Lab Med, Boston, MA 02111 USA

[26] Mayo Clin, Div Hematol & Med Oncol, Scottsdale, AZ 85054 USA

[27] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[28] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[29] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, New York, NY 10065 USA

[30] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

来源：

CELL REPORTS | 2016年 / 14卷 / 10期

关键词：

CANCER; EXPRESSION; EVEROLIMUS; MUTATIONS; LANDSCAPE; DISCOVERY; SURVIVAL; BAP1;

D O I：

10.1016/j.celrep.2016.02.024

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset.

引用

页码：2476 / 2489

页数：14

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