Transcription of the human prolactin gene in mammary cells

被引：13

作者：

Baudhuin, A ^{[1
]}

Manfroid, I ^{[1
]}

Van de Weerdt, C ^{[1
]}

Martial, JA ^{[1
]}

Muller, M ^{[1
]}

机构：

[1] Univ Liege, Inst Chim B6, Lab Biol Mol & Genie Genet, B-4000 Sart Tilman Par Liege, Belgium

来源：

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷

关键词：

prolactin; mammary cells; regulation; Pit-1;

D O I：

10.1111/j.1749-6632.2002.tb04682.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of human prolactin in the Mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human prolactin gene in mammary cells. Analysis of this regulation, and comparison to that in the pituitary, will contribute to a better understanding of mammary gland development and tumor formation. Here we present the first extensive analysis of the transcriptional regulation of the human prolactin gene in human mammary tumor cells.

引用

页码：454 / 458

页数：5

共 13 条

[1] SERUM IMMUNOREACTIVE AND BIOACTIVE LACTOGENIC HORMONES IN ADVANCED BREAST-CANCER PATIENTS TREATED WITH BROMOCRIPTINE AND OCTREOTIDE
ANDERSON, E
FERGUSON, JE
MORTEN, H
SHALET, SM
ROBINSON, EL
HOWELL, A
[J]. EUROPEAN JOURNAL OF CANCER, 1993, 29A (02) : 209 - 217
[2] Extrapituitary prolactin: Distribution, regulation, functions, and clinical aspects
BenJonathan, N
Mershon, JL
Allen, DL
Steinmetz, RW
[J]. ENDOCRINE REVIEWS, 1996, 17 (06) : 639 - 669
[3] CLEVENGER CV, 1995, AM J PATHOL, V146, P695
[4] PROLACTIN RECEPTOR ANTAGONISTS THAT INHIBIT THE GROWTH OF BREAST-CANCER CELL-LINES
FUH, G
WELLS, JA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) : 13133 - 13137
[5] GINSBURG E, 1995, CANCER RES, V55, P2591
[6] The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis
Kim, H
Muller, WJ
[J]. EXPERIMENTAL CELL RESEARCH, 1999, 253 (01) : 78 - 87
[7] LEPROVOST F, 1994, NEUROENDOCRINOLOGY, V60, P305, DOI 10.1159/000126763
[8] Involvement of prolactin in breast cancer: redefining the molecular targets
Llovera, M
Touraine, P
Kelly, PA
Goffin, V
[J]. EXPERIMENTAL GERONTOLOGY, 2000, 35 (01) : 41 - 51
[9] Inhibition of protein phosphatase PP1 in GH3B6, but not in GH3 cells, activates the MEK/ERK/c-fos pathway and the human prolactin promoter, involving the coactivator CBP/p300
Manfroid, I
Martial, JA
Muller, M
[J]. MOLECULAR ENDOCRINOLOGY, 2001, 15 (04) : 625 - 637
[10] Transcriptional regulation of the human prolactin gene
Muller, M
Berwaer, M
Caccavelli, L
Manfroid, I
Nalda, A
Pendeville, H
Pernasetti, F
van de Weerdt, C
Peers, B
Martial, JA
[J]. M S-MEDECINE SCIENCES, 1998, 14 (05): : 580 - 587

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