Vulnerability to depression: what is the role of stress genes in gene x environment interaction?

被引：44

作者：

El Hage, W. ^{[1
,2
]}

Powell, J. F. ^{[1
]}

Surguladze, S. A. ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

[2] Univ Tours, CHRU Tours, ERL CNRS 3106, INSERM,U930, Tours, France

来源：

PSYCHOLOGICAL MEDICINE | 2009年 / 39卷 / 09期

关键词：

HPA axis; serotonin; depression; genes; GLUCOCORTICOID-RECEPTOR GENE; SEROTONIN TRANSPORTER; MAJOR DEPRESSION; MORNING CORTISOL; LIFE-STRESS; MODERATION; AMYGDALA; RISK; AXIS; POLYMORPHISMS;

D O I：

10.1017/S0033291709005236

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-ad renal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, psychological Medicine 2008, 38, 307-313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene x environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.

引用

页码：1407 / 1411

页数：5

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