Five new steroidal saponins from Solanum chrysotrichum leaves and their antimycotic activity

被引：51

作者：

Zamilpa, A

Tortoriello, J

Navarro, V

Delgado, G

Alvarez, L

机构：

[1] Inst Mexicano Seguro Social, Ctr Invest Biomed Sur, Ctr, Morelos, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[3] Univ Autonoma Estado Morelos, Ctr Investigac Quim, Cuernavaca 62210, Morelos, Mexico

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 12期

关键词：

D O I：

10.1021/np020261h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Using bioactivity-directed isolation procedures, five new spirostan saponins and two sterol glycosides have been isolated from Solanum chrysotrichum leaves. The structure of these compounds was established based upon spectroscopic measurements, especially 1D and 2D NMR data of their peracetate derivatives. These compounds showed antimycotic activity. The most active compound is 6alpha-O-beta-D-xylopyranosyl-(1-->3)-beta-D-quinovopyranosyl-(25R)-5alpha-spirostan-3beta,23alpha-ol (2) (MIC = 12.5, 12.5, 100, and 200 mug/mL against Trichophyton mentagrophytes, T. rubrum, Aspergillis niger, and Candida albicans, respectively).

引用

页码：1815 / 1819

页数：5

共 16 条

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