Strategies for the synthesis of fusicoccanes by Nazarov reactions of dolabelladienones: Total synthesis of (+)-fusicoauritone

被引：69

作者：

Williams, David R. ^{[1
]}

Robinson, Leslie A. ^{[1
]}

Nevill, C. Richard ^{[1
]}

Reddy, Jayachandra P. ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 06期

关键词：

fusicoccanes; Julia condensation; medium-ring compounds; Nazarov cyclization; total synthesis;

D O I：

10.1002/anie.200603853

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Attaining closure: A synthetic pathway leading to (+)-fusicoauritone (1) is highlighted by the use of a Julia condensation for preparation of an eleven-membered-dolabelladienone precursor for subsequent Nazarov cyclization to yield the 5-8-5 tricyclic diterpene skeleton. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：915 / 918

页数：4

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