Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent

被引：508

作者：

Park, Yong Il ^{[2
]}

Kim, Jeong Hyun ^{[2
]}

Lee, Kang Taek ^{[1
]}

Jeon, Ki-Seok ^{[1
]}

Bin Na, Hyon ^{[2
]}

Yu, Jung Ho ^{[2
]}

Kim, Hyung Min ^{[1
]}

Lee, Nohyun ^{[2
]}

Choi, Seung Hong ^{[3
]}

Baik, Sung-Il ^{[4
]}

Kim, Hyoungsu ^{[3
]}

Park, Seung Pyo ^{[2
]}

Park, Beom-Jin ^{[5
]}

Kim, Young Woon ^{[4
]}

Lee, Sung Ho ^{[5
]}

Yoon, Soo-Young ^{[6
]}

Song, In Chan ^{[3
]}

Moon, Woo Kyung ^{[3
]}

Suh, Yung Doug ^{[1
]}

Hyeon, Taeghwan ^{[2
]}

机构：

[1] Korea Res Inst Chem Technol, NanoBio Fus Res Ctr, Taejon 305600, South Korea

[2] Seoul Natl Univ, Ctr Oxide Nanocrystalline Mat, Sch Chem & Biol Eng, Seoul 151744, South Korea

[3] Seoul Natl Univ Hosp, Seoul 110744, South Korea

[4] Seoul Natl Univ, Sch Mat Sci & Eng, Seoul 151744, South Korea

[5] Korea Univ, Coll Med, Anam Hosp, Seoul 136705, South Korea

[6] Korea Univ, Lab Med, Ansan Hosp, Coll Med, Ansan 425707, South Korea

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 44期

关键词：

SOLUBLE QUANTUM DOTS; UP-CONVERSION; IN-VIVO; BLINKING; NANOCRYSTALS; EMISSION; SPECTROSCOPY; EXCITATION; CORE; IONS;

D O I：

10.1002/adma.200901356

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+, Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background-free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long-term imaging experiments. Owing to Gd3+ ions in the host matrix, contrast is enhanced in T-1-weighted MRI.

引用

页码：4467 / +

页数：6

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