CSH guidelines for the diagnosis and treatment of drug-induced liver injury

被引：333

作者：

Yu, Yue-cheng ^{[1
]}

Mao, Yi-min ^{[2
]}

Chen, Cheng-wei ^{[3
]}

Chen, Jin-jun ^{[4
]}

Chen, Jun ^{[5
]}

Cong, Wen-ming ^{[6
]}

Ding, Yang ^{[7
]}

Duan, Zhong-ping ^{[8
]}

Fu, Qing-chun ^{[3
]}

Guo, Xiao-yan ^{[9
]}

Hu, Peng ^{[10
]}

Hu, Xi-qi ^{[11
]}

Jia, Ji-dong ^{[12
]}

Lai, Rong-tao ^{[13
]}

Li, Dong-liang ^{[14
]}

Liu, Ying-xia ^{[15
]}

Lu, Lun-gen ^{[16
]}

Ma, Shi-wu ^{[17
]}

Ma, Xiong ^{[2
]}

Nan, Yue-min ^{[18
]}

Ren, Hong ^{[10
]}

Shen, Tao ^{[19
,20
]}

Wang, Hao ^{[21
]}

Wang, Ji-yao ^{[22
]}

Wang, Tai-ling ^{[23
]}

Wang, Xiao-jin ^{[3
]}

Wei, Lai ^{[21
]}

Xie, Qing ^{[13
]}

Xie, Wen ^{[24
]}

Yang, Chang-qing ^{[25
]}

Yang, Dong-liang ^{[26
]}

Yu, Yan-yan ^{[27
]}

Zeng, Min-de ^{[2
]}

Zhang, Li ^{[28
]}

Zhao, Xin-yan ^{[12
]}

Zhuang, Hui ^{[19
,20
]}

机构：

[1] Nanjing Univ Chinese Med, Bayi Hosp, Liver Dis Ctr PLA, Nanjing 210002, Jiangsu, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Gastroenterol, Shanghai 200001, Peoples R China

[3] Nanjing Mil Command, Shanghai Liver Dis Res Ctr, Hosp 85, Nanjing 200235, Jiangsu, Peoples R China

[4] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Hepatol Unit, Guangzhou 510515, Guangdong, Peoples R China

[5] Cent S Univ, Xiangya Hosp 2, Liver Dis Ctr, Changsha 410011, Hunan, Peoples R China

[6] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Pathol, Shanghai 201805, Peoples R China

[7] China Med Univ, Dept Infect Dis, Shengjing Hosp, Shenyang 110004, Peoples R China

[8] Capital Med Univ, Beijing Youan Hosp, Artificial Liver Ctr, Beijing 100069, Peoples R China

[9] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Gastroenterol, Xian 710004, Peoples R China

[10] Chongqing Med Univ, Inst Viral Hepatitis, Affiliated Hosp 2, Dept Infect Dis, Chongqing 400010, Peoples R China

[11] Fudan Univ, Sch Med, Dept Pathol, Shanghai 200433, Peoples R China

[12] Capital Medial Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100069, Peoples R China

[13] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Infect Dis, Shanghai 200025, Peoples R China

[14] PLA, Dept Hepatobiliary Dis, Fuzhou Gen Hosp, Fuzhou 350025, Peoples R China

[15] Shenzhen Third Peoples Hosp, Dept Liver Dis, Shenzhen 518040, Peoples R China

[16] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Gastroenterol, Shanghai 200080, Peoples R China

[17] PLA, Dept Infect Dis, Kunming Gen Hosp, Kunming 650032, Peoples R China

[18] Hebei Med Univ, Affiliated Hosp 3, Dept Tradit & Western Med Hepatol, Shijiazhuang 050051, Peoples R China

[19] Beijing Univ, Dept Microbiol, Beijing 100083, Peoples R China

[20] Beijing Univ, Sch Basic Med Sci, Infect Dis Ctr, Beijing 100083, Peoples R China

[21] Beijing Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

[22] Fudan Univ, Sch Med, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China

[23] Capital Med Univ, China Japan Friendship Hosp, Dept Pathol, Beijing 100029, Peoples R China

[24] Capital Med Univ, Beijing Ditan Hosp, Ctr Liver Dis, Beijing 100011, Peoples R China

[25] Tongji Univ, Sch Med, Tongji Hosp, Dept Gastroenterol, Shanghai 200065C, Peoples R China

[26] Huazhong Univ Sci & Technol, Union Hosp, Dept Infect Dis, Tongji Med Coll, Wuhan 430022, Peoples R China

[27] Beijing Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China

[28] Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100078C, Peoples R China

来源：

HEPATOLOGY INTERNATIONAL | 2017年 / 11卷 / 03期

关键词：

Drug-induced liver injury; Epidemiology; Pathogenesis; Pathology; Clinical type; Diagnosis; Differential diagnosis; Treatment; Prevention; Recommendations; INTRAVENOUS N-ACETYLCYSTEINE; UNFOLDED PROTEIN RESPONSE; CAUSALITY ASSESSMENT; CLINICAL-FEATURES; AUTOIMMUNE HEPATITIS; UNITED-STATES; RISK-FACTORS; ANTITUBERCULOSIS TREATMENT; FUNCTION TESTS; GENOME-WIDE;

D O I：

10.1007/s12072-017-9793-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells. The CSH guidelines summarized the epidemiology, pathogenesis, pathology, and clinical manifestation and gives 16 evidence-based recommendations on diagnosis, differential diagnosis, treatment, and prevention of DILI.

引用

页码：221 / 241

页数：21

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