Myocarditis

被引:456
作者
Fung, Gabriel [1 ,2 ]
Luo, Honglin [1 ,2 ]
Qiu, Ye [1 ,2 ]
Yang, Decheng [1 ,2 ]
McManus, Bruce [1 ,2 ,3 ,4 ]
机构
[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V6Z 1Y6, Canada
[2] Univ British Columbia, Ctr Heart Lung Innovat, Vancouver, BC V6Z 1Y6, Canada
[3] Univ British Columbia, Ctr Excellence Prevent Organ Failure, PROOF Ctr, Vancouver, BC V6Z 1Y6, Canada
[4] Univ British Columbia, Inst Heart Lung Hlth, St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada
基金
加拿大健康研究院;
关键词
myocarditis; heart diseases; communicable diseases; virus diseases; cardiovascular infections; COXSACKIEVIRUS B3 REPLICATION; CARDIOVASCULAR MAGNETIC-RESONANCE; AMERICAN-HEART-ASSOCIATION; ENTEROVIRAL PROTEASE 2A; COLLEGE-OF-CARDIOLOGY; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTOR-3; EXPERIMENTAL AUTOIMMUNE MYOCARDITIS; VENTRICULAR ENDOMYOCARDIAL BIOPSY; DECAY-ACCELERATING FACTOR;
D O I
10.1161/CIRCRESAHA.115.306573
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention.
引用
收藏
页码:496 / 514
页数:19
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