Thiopeptide Antibiotic Biosynthesis

被引：46

作者：

Arndt, Hans-Dieter ^{[1
,2
]}

Schoof, Sebastian ^{[1
,2
]}

Lu, Jin-Yong ^{[1
,2
]}

机构：

[1] Tech Univ Dortmund, Fak Chem, D-44221 Dortmund, Germany

[2] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 37期

关键词：

antibiotics; biosynthesis; natural products; ribosomal peptides; thiopeptides; PEPTIDE; THIOSTREPTON; CONSTRUCTION; TRYPTOPHAN; CHEMISTRY; PATHWAY; GE2270A; BINDING; DOMAIN; L11;

D O I：

10.1002/anie.200901808

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Tailors at work: The structurally intriguing thiopeptide antibiotic natural products have been conclusively and universally shown to be biosynthesized from genetically encoded linear precursor peptides by novel tailoring enzymes. These unique findings challenge previously accepted biosynthesis paradigms and are expected to inspire future discoveries in the chemistry and biology of peptide natural products. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6770 / 6773

页数：4

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