The St. Thomas' UK adult twin registry

被引：75

作者：

Spector, TD ^{[1
]}

MacGregor, AJ ^{[1
]}

机构：

[1] St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London SE1 7EH, England

来源：

TWIN RESEARCH | 2002年 / 5卷 / 05期

关键词：

D O I：

10.1375/twin.5.5.440

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Registry consists of nearly 10,000 monozygous and dizygous adult caucasian twins aged 18-80 from all over the UK and was started in 1993. This is a volunteer sample recruited by successive media campaigns without selecting for particular diseases or traits. All twins receive a series of disease questionnaires. In addition over half the twins have been assessed in detail clinically for several hundred phenotypes related to common diseases or intermediate traits, The focus has been primarily on cardiovascular, metabolic, musculoskeletal, dermatological, and opthalmological diseases. Over 3000 DZ twins have had a genome wide scan performed as well as many candidate genes allowing both linkage and association studies. The registry has led to many successful innovative research projects, particularly in common diseases previously thought to be predominantly environmental and helped positionally clone some novel genes for common diseases.

引用

页码：440 / 443

页数：4

共 29 条

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