One-step homogeneous detection of DNA hybridization with gold nanoparticle probes by using a linear light-scattering technique

被引：152

作者：

Du, Bao-An ^{[1
]}

Li, Zheng-Ping ^{[1
]}

Liu, Cheng-Hui ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei Province, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 47期

关键词：

base-pair mismatches; DNA recognition; gold nanoparticles; light scattering; nucleoticles;

D O I：

10.1002/anie.200603331

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Matchmaker, matchmaker: A gold-nanoparticle-based light-scattering assay has been developed for sensitive detection of DNA hybridization. The assay relies on the enhancement of light scattering that originates from the aggregation of oligonucleotide-functionalized gold nanoparticles directed by the target DNA. The assay also exhibits a high degree of discrimination between perfectly matched target DNA and targets with single base-pair mismatches. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8022 / 8025

页数：4

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