Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis

被引：227

作者：

Ito, J

Chang, FR

Wang, HK

Park, YK

Ikegaki, M

Kilgore, N

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] Kaohsiung Med Coll, Grad Inst Nat Prod, Kaohsiung, Taiwan

[3] Univ Estadual Campinas, UNICAMP, Coll Food Engn, BR-13081970 Campinas, SP, Brazil

[4] Panacos Pharmaceut, Gaithersburg, MD 20877 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 10期

关键词：

D O I：

10.1021/np010211x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC50 <0.1 mug/mL, TI > 186) and was modified to develop more potent anti-AIDS agents.

引用

收藏

页码：1278 / 1281

页数：4

相关论文

共 24 条

[1] TERPENOIDS, ALKALOIDS AND COUMARINS FROM BORONIA-INORNATA AND BORONIA-GRACILIPES [J].

AHSAN, M ;

ARMSTRONG, JA ;

GRAY, AI ;

WATERMAN, PG .

PHYTOCHEMISTRY, 1995, 38 (05) :1275-1278

[2]

Basnet P, 1997, Z NATURFORSCH C, V52, P828

[3] OLEANANE BENZOATES FROM THE BARK OF PLOIARIUM-ALTERNIFOLIUM [J].

BENNETT, GJ ;

HARRISON, LJ ;

SIA, GL ;

SIM, KY ;

CONNOLLY, JD .

PHYTOCHEMISTRY, 1992, 31 (04) :1325-1327

[4] ENT-LABDANES FROM BACCHARIS-STERNBERGIANA [J].

BOHLMANN, F ;

SCHEIDGES, C ;

ZDERO, C ;

KING, RM ;

ROBINSON, H .

PHYTOCHEMISTRY, 1984, 23 (05) :1109-1111

[5] LIGHT-INDUCED, IODINE-CATALYZED AEROBIC OXIDATION OF UNSATURATED TERTIARY-AMINES [J].

GANGLOFF, AR ;

JUDGE, TM ;

HELQUIST, P .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (11) :3679-3682

[6] Anti-AIDS agents - XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives [J].

Hashimoto, F ;

Kashiwada, Y ;

Cosentino, LM ;

Chen, CH ;

Garrett, PE ;

Lee, KH .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (12) :2133-2143

[7] Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids [J].

Kashiwada, Y ;

Wang, HK ;

Nagao, T ;

Kitanaka, S ;

Yasuda, I ;

Fujioka, T ;

Yamagishi, T ;

Cosentino, LM ;

Kozuka, M ;

Okabe, K ;

Ikeshiro, Y ;

Hu, CQ ;

Yeh, E ;

Lee, KH .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (09) :1090-1095

[8] Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis [J].

Kimoto, T ;

Arai, S ;

Kohguchi, M ;

Aga, M ;

Nomura, Y ;

Micallef, MJ ;

Kurimoto, M ;

Mito, K .

CANCER DETECTION AND PREVENTION, 1998, 22 (06) :506-515

[9]

LI L-N, 1989, Planta Medica, V55, P294, DOI 10.1055/s-2006-962010

[10] ANWUWEIZONIC ACID AND MANWUWEIZIC ACID, THE PUTATIVE ANTICANCER ACTIVE PRINCIPLE OF SCHISANDRA-PROPINQUA [J].

LIU, JS ;

HUANG, MF ;

TAO, Y .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1988, 66 (03) :414-415