Alterations of metabolic genes and metabolites in cancer

被引：96

作者：

Oermann, Eric K. ^{[1
,2
]}

Wu, Jing ^{[1
,2
]}

Guan, Kun-Liang ^{[3
,4
,5
]}

Xiong, Yue ^{[1
,3
,6
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Neurosurg, Chapel Hill, NC 27599 USA

[3] Fudan Univ, Inst Biomed Sci, Mol & Cell Biol Lab, Shanghai 200032, Peoples R China

[4] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[6] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2012年 / 23卷 / 04期

关键词：

Cancer; Metabolism; Warburg; Oncometabolite; Tumorigenesis; INTEGRATED GENOMIC ANALYSIS; RAT PYRUVATE-KINASE; FUMARATE HYDRATASE; IDH2; MUTATIONS; MESSENGER-RNA; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; P53-INDUCIBLE REGULATOR; SUCCINATE-DEHYDROGENASE; LACTATE-DEHYDROGENASE; RESPONSE ELEMENTS;

D O I：

10.1016/j.semcdb.2012.01.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings-the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer-have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：370 / 380

页数：11

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