Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: role of antioxidation

被引：66

作者：

Chao, CC

Lee, EHY ^{[1
]}

机构：

[1] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[2] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 06期

关键词：

glial cell line-derived neurotrophic factor; glutathione peroxidase; superoxide dismutase; catalase; dopamine; 1-methyl-4-phenylpyridinium;

D O I：

10.1016/S0028-3908(99)00030-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：913 / 916

页数：4

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