Extracellular transglutaminase 2 activates β-catenin signaling in calcifying vascular smooth muscle cells

被引：59

作者：

Faverman, Lidia ^{[1
]}

Mikhaylova, Lyudmila ^{[1
]}

Malmquist, Jennifer ^{[1
]}

Nurminskaya, Maria ^{[1
]}

机构：

[1] Tufts Univ, Dept Anat & Cell Biol, Boston, MA 02111 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 10期

关键词：

vascular smooth muscle cell; calcification; transglutaminase; 2; beta-catenin;

D O I：

10.1016/j.febslet.2008.03.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Accumulation of transglutaminase 2 (TG2) is often associated with mineral deposits in vasculature. Here, we demonstrate that purified TG2 stimulated a 3-fold increase in matrix mineralization and up-regulation of osteoblastic markers in cultured primary vascular smooth muscle cells (VSMCs). Extracellular TG2 interacts with the low density lipoprotein related-protein 5 receptor and activates beta-catenin signaling in VSMCs. These results suggest that TG2 may promote vascular calcification by activating the beta-catenin signaling pathway. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

收藏

页码：1552 / 1557

页数：6

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