Tissue factor activity and function in blood coagulation

被引：34

作者：

Butenas, Saulius ^{[1
]}

Orfeo, Thomas ^{[1
]}

Mann, Kenneth G. ^{[1
]}

机构：

[1] Univ Vermont, Dept Biochem, Burlington, VT 05405 USA

来源：

THROMBOSIS RESEARCH | 2008年 / 122卷

关键词：

tissue factor; posttranstational modifications; monocytes; thrombin generation; haemorrhage control;

D O I：

10.1016/S0049-3848(08)70018-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue factor (TF) is the major physiological initiator of blood coagulation. It exists as an integral membrane protein that upon injury to the blood vessel becomes exposed to the blood stream and initiates a series of enzymatic reactions that cause blood to clot. TF is also found within circulating blood cells, requiring specific signaling events to promote its expression. In this review we will discuss current controversies concerning the structure-activity relationships of TF and contributions of TF to the hemostatic process, the potential roles of intravascular TF, including non-cell-bound TF and cell-expressed TF and the overall relationship between TF function and hemorrhage control. (c) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：S42 / S46

页数：5

相关论文

共 32 条

[1] Disulfide isomerization switches tissue factor from coagulation to cell signaling [J].

Ahamed, Jasimuddin ;

Versteeg, Henri H. ;

Kerver, Marjolein ;

Chen, Vivien M. ;

Mueller, Barbara M. ;

Hogg, Philip J. ;

Ruf, Wolfram .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :13932-13937

[2] Tissue factor encryption [J].

Bach, RR .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (03) :456-461

[3] Platelets, circulating tissue factor, and fibrin colocalize in ex vivo thrombi: real-time fluorescence images of thrombus formation and propagation under defined flow conditions [J].

Balasubramanian, V ;

Grabowski, E ;

Bini, A ;

Nemerson, Y .

BLOOD, 2002, 100 (08) :2787-2792

[4] Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism [J].

Berckmans, RJ ;

Nieuwland, R ;

Tak, PP ;

Böing, AN ;

Romijn, FPHTM ;

Kraan, MC ;

Breedveld, FC ;

Hack, CE ;

Sturk, A .

ARTHRITIS AND RHEUMATISM, 2002, 46 (11) :2857-2866

[5]

Berckmans RJ, 2001, THROMB HAEMOSTASIS, V85, P639

[6] SERUM STIMULATION OF QUIESCENT HUMAN-FIBROBLASTS INDUCES THE SYNTHESIS OF TISSUE FACTOR MESSENGER-RNA FOLLOWED BY THE APPEARANCE OF TISSUE FACTOR ANTIGEN AND PROCOAGULANT ACTIVITY [J].

BLOEM, LJ ;

CHEN, L ;

KONIGSBERG, WH ;

BACH, R .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 139 (02) :418-423

[7] Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein [J].

Bogdanov, VY ;

Balasubramanian, V ;

Hathcock, J ;

Vele, O ;

Lieb, M ;

Nemerson, Y .

NATURE MEDICINE, 2003, 9 (04) :458-462

[8] The participation of leukocytes in coagulant reactions [J].

Bouchard, BA ;

Tracy, PB .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (03) :464-469

[9]

Butenas S, 2006, FASEB J, V20, pA47

[10]

Butenas S, 2004, BLOOD, V104, p39A

← 1 2 3 4 →