Increased Cerebrospinal Fluid Aβ38/Aβ42 Ratio in Alzheimer Disease

被引：22

作者：

Mehta, Pankaj D. ^{[1
]}

Pirttila, Tuula ^{[2
]}

机构：

[1] New York State Off Mental Retardat & Dev Disabil, Inst Basic Res, Staten Isl, NY USA

[2] Kuopio Univ Hosp, SF-70210 Kuopio, Finland

来源：

NEURODEGENERATIVE DISEASES | 2005年 / 2卷 / 05期

关键词：

Alzheimer disease; cerebrospinal fluid; Amyloid beta 1-38; Amyloid beta 1-40; Amyloid beta 1-42; Enzyme-linked immunosorbent assay;

D O I：

10.1159/000090363

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We quantitated amyloid beta peptide (A beta) 38, A beta 40 and A beta 42 levels in matched CSF and plasma from Alzheimer disease (AD) patients and controls. CSF A beta 38 and A beta 40 levels were similar in AD patients and in controls; however, they were higher in controls with APOE epsilon 4 allele than those without. CSF A beta 42 levels were lower in AD patients than in controls. The CSF A beta 38/42 ratio was higher in AD patients than controls, consistent with the previously reported higher A beta 40/42 ratio. A beta 38, A beta 40 and A beta 42 levels in plasma were similar in AD patients and in controls and showed no relationship to levels in CSF. Our findings suggest that the increased CSF A beta 38/42 ratio found in AD patients is derived entirely from reduction of CSF A beta 42 levels. Copyright (C) 2005 S. Karger AG, Basel

引用

页码：242 / 245

页数：4

共 14 条

[1] Strategies for disease modification in Alzheimer's disease [J].

Citron, M .

NATURE REVIEWS NEUROSCIENCE, 2004, 5 (09) :677-685

[2] Value of CSF β-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment [J].

Hampel, H ;

Teipel, SJ ;

Fuchsberger, T ;

Andreasen, N ;

Wiltfang, J ;

Otto, M ;

Shen, Y ;

Dodel, R ;

Du, Y ;

Farlow, M ;

Möller, HJ ;

Blennow, K ;

Buerger, K .

MOLECULAR PSYCHIATRY, 2004, 9 (07) :705-710

[3] Longitudinal study of cerebrospinal fluid levels of tau, Aβ1-40, and Aβ1-42(43) in Alzheimer's disease:: A study in Japan [J].

Kanai, M ;

Matsubara, E ;

Isoe, K ;

Urakami, K ;

Nakashima, K ;

Arai, H ;

Sasaki, H ;

Abe, K ;

Iwatsubo, T ;

Kosaka, T ;

Watanabe, M ;

Tomidokoro, Y ;

Shizuka, M ;

Mizushima, K ;

Nakamura, T ;

Igeta, Y ;

Ikeda, Y ;

Amari, M ;

Kawarabayashi, T ;

Ishiguro, K ;

Harigaya, Y ;

Wakabayashi, K ;

Okamoto, K ;

Hirai, S ;

Shoji, M .

ANNALS OF NEUROLOGY, 1998, 44 (01) :17-26

[4] The effects of age, apolipoprotein E phenotype and gender on the concentration of amyloid-β (Aβ) 40, Aβ42, apolipoprotein E and transthyretin in human cerebrospinal fluid [J].

Kunicki, S ;

Richardson, J ;

Mehta, PD ;

Kim, KS ;

Zorychta, E .

CLINICAL BIOCHEMISTRY, 1998, 31 (05) :409-415

[5] Amyloid-β peptides interact with plasma proteins and erythrocytes:: Implications for their quantitation in plasma [J].

Kuo, YM ;

Kokjohn, TA ;

Kalback, W ;

Luehrs, D ;

Galasko, DR ;

Chevallier, N ;

Koo, EH ;

Emmerling, MR ;

Roher, AE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 268 (03) :750-756

[6] Neurochemical diagnosis of Alzheimer's dementia by CSF Aβ42, Aβ42/Aβ40 ratio and total tau [J].

Lewczuk, P ;

Esselmann, H ;

Otto, M ;

Maler, JM ;

Henkel, AW ;

Henkel, MK ;

Eikenberg, O ;

Antz, C ;

Krause, WR ;

Reulbach, U ;

Kornhuber, J ;

Wiltfang, J .

NEUROBIOLOGY OF AGING, 2004, 25 (03) :273-281

[7] Electrophoretic separation of amyloid β peptides in plasma [J].

Lewczuk, P ;

Esselmann, H ;

Bibl, M ;

Paul, S ;

Svitek, J ;

Miertschischk, J ;

Meyrer, R ;

Smirnov, A ;

Maler, JM ;

Klein, C ;

Otto, M ;

Bleich, S ;

Sperling, W ;

Kornhuber, J ;

Rüther, E ;

Wiltfang, J .

ELECTROPHORESIS, 2004, 25 (20) :3336-3343

[8] Plasma Aβ40 and Aβ42 and Alzheimer's disease -: Relation to age, mortality, and risk [J].

Mayeux, R ;

Honig, LS ;

Tang, MX ;

Manly, J ;

Stern, Y ;

Schupf, N ;

Mehta, PD .

NEUROLOGY, 2003, 61 (09) :1185-1190

[9] Plasma amyloid β protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome [J].

Mehta, PD ;

Mehta, SP ;

Fedor, B ;

Patrick, BA ;

Emmerling, M ;

Dalton, AJ .

NEUROSCIENCE LETTERS, 2003, 342 (03) :155-158

[10] Amyloid β protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease [J].

Mehta, PD ;

Pirttila, T ;

Patrick, BA ;

Barshatzky, M ;

Mehta, SP .

NEUROSCIENCE LETTERS, 2001, 304 (1-2) :102-106

← 1 2 →