Salmonella enterica serovar Typhimurium ompS1 and ompS2 mutants are attenuated for virulence in mice

被引：40

作者：

Rodríguez-Morales, O ^{[1
]}

Fernández-Mora, M ^{[1
]}

Hernández-Lucas, I ^{[1
]}

Vázquez, A ^{[1
]}

Puente, JL ^{[1
]}

Calva, E ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Biotechnol, Dept Microbiol Mol, Cuernavaca 62210, Morelos, Mexico

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 02期

关键词：

D O I：

10.1128/IAI.74.2.1398-1402.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Salmonella enterica serovar Typhimurium mutants with mutations in the ompS1 and ompS2 genes, which code for quiescent porins, were nevertheless highly attenuated for virulence in a mouse model, indicating a role in pathogenesis. Similarly, a strain with a mutation in the gene coding for LeuO, a positive regulator of ompS2, was also attenuated.

引用

页码：1398 / 1402

页数：5

共 34 条

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