Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

被引：79

作者：

Mathew, RJ

Wilson, WH

Chiu, NY

Turkington, TG

Degrado, TR

Coleman, RE

机构：

[1] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA

[3] Changhua Christian Hosp, Dept Psychiat, Changhua, Taiwan

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1999年 / 100卷 / 01期

关键词：

depersonalization; tetrahydrocannabinol (THC); positron emission tomography (PET); cerebral blood flow (CBF);

D O I：

10.1111/j.1600-0447.1999.tb10916.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

引用

页码：67 / 75

页数：9

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