共 35 条
Chemosensing in Escherichia coli:: Two regimes of two-state receptors
被引:167
作者:
Keymer, JE
Endres, RG
Skoge, M
Meir, Y
Wingreen, NS
[1
]
机构:
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
[2] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA
[3] NEC Labs Amer Inc, Princeton, NJ 08540 USA
[4] Ben Gurion Univ Negev, Dept Phys, IL-84105 Beer Sheva, Israel
来源:
关键词:
chemotaxis;
Monod;
Wyman;
and Changeux model;
receptor clustering;
D O I:
10.1073/pnas.0507438103
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The chemotaxis network in Escherichia coli is remarkable for its sensitivity to small relative changes in the concentrations of multiple chemical signals. We present a model for signal integration by mixed clusters of interacting two-state chemoreceptors. Our model results compare favorably to the results obtained by Sourjik and Berg with in vivo fluorescence resonance energy transfer. Importantly, we identify two distinct regimes of behavior, depending on the relative energies of the two states of the receptors. In regime 1, coupling of receptors leads to high sensitivity, while in regime 11, coupling of receptors leads to high cooperativity, i.e., high Hill coefficient. For homogeneous receptors, we predict an observable transition between regime I and regime 11 with increasing receptor methylation or amidation.
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页码:1786 / 1791
页数:6
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