Vaults are the answer, what is the question?

被引：68

作者：

Kickhoefer, VA ^{[1
]}

Vasu, SK ^{[1
]}

Rome, LH ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT BIOL,SAN DIEGO,CA 92093

来源：

TRENDS IN CELL BIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/0962-8924(96)10014-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vaults are large cytoplasmic ribonucleoprotein (RNP) particles of eukaryotic cells, whose considerable abundance and striking evolutionary conservation argue for an important general cellular function. Early studies on vaults focused on the structural features and cellular distribution of the particle and will only be summarized briefly here. In this article, we discuss the molecular characterization of vault components and describe genetic studies carried out in Dictyostelium. The recent finding that the major vault protein is elevated in non-P-glycoprotein multidrug resistant cancer cells has direct implications concerning the function of the vault particle and indicates a potential role for vaults in resistance of tumour cells to anticancer drugs.

引用

页码：174 / 178

页数：5

共 22 条

[1] VISUALIZATION OF TRANSPORT-RELATED CONFIGURATIONS OF THE NUCLEAR-PORE TRANSPORTER [J].