The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors

被引：186

作者：

Ottani, A

Leone, S

Sandrini, M

Ferrari, A

Bertolini, A

机构：

[1] Univ Modena & Reggio Emilia, Fac Med, Clin Pharmacol Sect, Dept Lab Serv,Policlin Modena, I-41100 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Biomed Sci, Pharmacol Sect, I-41100 Modena, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 531卷 / 1-3期

关键词：

paracetamol; CB1; receptor; analgesic activity;

D O I：

10.1016/j.ejphar.2005.12.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanism of the analgesic activity of paracetamol (acetaminophen), one of the most widely used drugs for the treatment of pain, is still not clear. Here we show that in rats, using the hot plate test, the analgesic effect of paracetamol is prevented by two antagonists at cannabinoid CB I receptors (AM281 and SR141716A) at doses that prevent the analgesic activity of the cannabinoid wCB(1) agonist HU210. Our present results suggest that paracetamol-induced antinociception involves the cannabinoid system. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：280 / 281

页数：2

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