Regulation of phosphatidylcholine homeostasis by Sec14

Phosphatidy1choline is the major phospholipid in eukaryotic cells and serves as both a permeability barrier as well as a modulator of a plethora of cellular and biological functions. This review touches on the importance of proper regulation of phosphatidy1choline metabolism on health, and discusses how yeast genetics has contributed to furthering our understanding of the precise Molecular events regulated by alterations in phosphatidy1choline metabolism. Yeast studies have determined that the phosphatidylcholine and (or) phosphatidylinositol binding protein, See 14, is a major regulator of phosphatidy1choline homeostasis. Sec14 itself regulates vesicular transport from the Golgi, and the interrelationship between phosphatidylcholine metabolism and membrane movement within the cell is described in detail. The recent convergence of the yeast genetic Studies with that of mammalian cell biology in how cells maintain phosphatidy1choline homeostasis is highlighted.